Research on Calcium Fructoborate (FruiteX-B)
SUMMARY AND STATS
- After just 4 weeks 80% those with mild to moderate joint pain stop taking or decreased their dose of medication.
- 87.5% of that same group had less or no stiffness in the same time.
- Almost 2/3 of this group were pain free or had significantly less pain after the 4 weeks.
- This number increased after 8 weeks with 2/3 of the participants stopping their pain medication altogether.
- At 8 weeks 3/4 of the severe oseoarthritis group had stopped using their pain medication or had decreased the amount taken.
Read the summary of each specific study below...
Evaluation of the Distribution of Calcium Fructoborate and Reference Compound in Rats
A company known as Vyrex Corporation did a study on boron in August of 1998. The data collected showed calcium fructoborate to be more bioavailable form of boron compared with boron citrate. The "nature-identical" calcium fructoborate was easier for the body to absorb and was more accessible for longer periods of time. The boron citrate was not as easily-absorbed and it was not as accessible by the body.
Calcium Fructoborate is a bioavailable form of Boron, but that is not where the story ends. CFB is also has been shown to be absorbed in its intact state. It has also been shown to have activity in the body as the form fructoborate. It is not just a form of boron. Being bioavailble is only one piece of the pie. It is also important to highlight that the fructobortate molecule stays intact through digestion and has activity that may be different and more beneficial than simple boron.
Detection of Intact Calcium Fructoborate (FruiteX-B) in Sera from Animals Treated with the Compound
Results from testing show that FruiteX-B allows for control that isn't available with raw boron. It can serve as a controlled-release form of boron in blood or tissues. The compound, fructoborate, stays completely intact throughout digestion until the body absorbs and utilizes it. This allows for more potent benefits than other boron compounds. Researchers found that FruiteX-B's unique biological effects are based on the fructoborate compound as a whole. Further research was suggested to better understand the benefits of this nature-identical compound and the way that it interacts with the body.
Fructoborate, Vitamin D/Steroid Hormone Homeostasis, and Bone Ash Accumulation
The University of Wisconsin (Madison) Department of Biochemistry looked into fructoborate in April, 2002. This study looked at fructoborate and its relationship with vitamin D. Vitamin D deficient animals saw a 5.8% in bone mineral content after receiving fructoborate. The boron compound also had a direct positive effect on bone density and mass. This shows a parallel between fructoborate intake and vitamin D absorption and use.
Vitamin D/Steroid Hormone Homeostasis and Calcium Fructoborate Supplementation
In March, 2002, the Department of Orthopedic Medicine at the University of Novi Sad also looked into calcium fructoborate. This study showed that it's an important part of many important processes in the body. Vitamin D saw a 19.6% increase with calcium fructoborate. DHEA also saw a great increase, this one of 56%. Free testosterone was also increased by an impressives 29.5%. One of the ways it is believed to positively affect vitamin D and DHEA levels is by blocking or inhibiting the affects of the enzyme system that breaks these nutrients down. Fructoborate is believed to help regulate the catabolic enzymatic hydroxylation process.
In Vitro Evaluation of Antioxidant Activity of Calcium Fructoborate
The Department of Biochemistry at the University of Craiova did a January, 2004 study on fructoborate. The work showed some interesting results in favor of calcium fructoborate. Results showed that it helped to inhibit oxidative stress in human cells. Because oxidative stress can contribute to some rather serious damage, this proves to be a large discovery in favor of FruiteX-B. Unfortunately, many people do not understand the severity of oxidative stress or its mechanisms.
In Vitro Effects of Calcium Fructoborate on FMLP-Stimulated Human Neutrophil Granulocytes
A research study published in the journal of Biological Trace Element Research in December of 2006 looked at Fructoborate's effects on different markers of inflammation and its antioxidant effects. Fructoborate slowed respiratory burst by 93% and decreased superoxide by 59%. These are two of the strongest forms of oxidation in the body that can lead to inflammation.
One of the most potent antioxidants in the body is SOD. Fructoborate demonstrated an ability to increase SOD levels by 72% in this study. SOD protects the body from superoxide and the inflammation that can be triggered by it. Other research has shown that boron can help stop the break down of glutathione, another powerful antioxidant in the body. So not only can boron act as an antioxidant, but this study showed it can boost the level of other antioxidants.
Osteoarthritis and Calcium Fructoborate Supplementation: An Open-Label Pilot Study
A January 2002 study by the Department of Orthopedic Medicine of the University of Novi Sad offered insight into calcium fructoborate's ability to fight pain and stiffness. Subjects who used FruiteX-B (calcium fructoborate) felt that they were able to reduce the use of pain medication. People with mild to moderate pain experienced massive increases in their comfort levels. The testing in this study showed that this boron compound was equal to if not better than glucosamine in handling the overall symptons of osteoarthritis. In this study subjects stated that their range of motion and overall functionality of the joint was better than subjects in a glucosamine study.
